Flybe is to offer flights to Ireland from London City Airport after signing a five-year deal.
The airline will offer services to Belfast and Dublin, as well as Inverness, Exeter and Edinburgh.
Flights are due to begin on October 27. Flybe estimates the routes will carry about 500,000 passengers a year.
"Today's announcement is a significant landmark in the re-birth of Flybe," said the airline's chief executive, Saad Hammad.
"We are delighted to re-enter the London market at London's most convenient airport."
Flybe is an Exeter-based airline operating over 180 routes to 65 European airports.
It is Europe’s largest regional airline, but the airline has suffered losses in the past few years. In November last year, it announced plans to close several of its regional bases.
The airline’s bosses hope that the latest operation from London City Airport will revive Flybe’s fortunes.
The airline also plans to introduce to services to European ski resorts, as well as to destinations in France and northern Spain.